Clinical Pharmacokinetic Studies of Enzalutamide
نویسندگان
چکیده
منابع مشابه
Clinical Pharmacokinetic Studies of Enzalutamide
BACKGROUND AND OBJECTIVES Oral enzalutamide (160 mg once daily) is approved for the treatment of metastatic castration-resistant prostate cancer (mCRPC). This article describes the pharmacokinetics of enzalutamide and its active metabolite N-desmethyl enzalutamide. METHODS Results are reported from five clinical studies. RESULTS In a dose-escalation study (n = 140), enzalutamide half-life w...
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BACKGROUND AND OBJECTIVES Two phase I drug interaction studies were performed with oral enzalutamide, which is approved for the treatment of metastatic castration-resistant prostate cancer (mCRPC). METHODS A parallel-treatment design (n = 41) was used to evaluate the effects of a strong cytochrome P450 (CYP) 2C8 inhibitor (oral gemfibrozil 600 mg twice daily) or strong CYP3A4 inhibitor (oral ...
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ژورنال
عنوان ژورنال: Clinical Pharmacokinetics
سال: 2015
ISSN: 0312-5963,1179-1926
DOI: 10.1007/s40262-015-0271-5